Howmet Aerospace (HWM) prices $1.2B senior notes to fund $1.8B acquisition of Consolidated Aerospace Manufacturing - Notes split into $400M (3.75%, 2028), $300M (3.9%, 2029), and $500M (4.75%, 2036) tranches - Offering managed by Citigroup, Goldman Sachs, J.P. Morgan, and SMBC Nikko Securities - Combined with $600M additional borrowings and cash to complete acquisition - Expected closing date March 3, 2026, subject to customary conditions #Form8K #Debt #Acquisition Full summary: www.perivis.com/note/4... $HWM.US

Howmet Aerospace (HWM) plans senior notes offering to help finance $1.8B acquisition of Consolidated Aerospace Manufacturing - Senior notes proceeds combined with $600M commercial paper borrowings and cash to fund purchase - Offering under existing shelf registration; terms subject to market conditions - Acquisition aims to expand aerospace manufacturing capabilities and operational scale - Increased debt expected to impact leverage and capital structure post-transaction #Form8K #Debt #Acquisition Full summary: www.perivis.com/note/d... $HWM.US

Recall of Quest Cat Food Chicken Nuggets due to low Thiamine levels • Single lot (C25288, BB 10/15/2027) nationwide distribution in US states including CA, TX, IL • Low Thiamine (Vitamin B1) identified after illness report; symptoms include neurological and GI issues • One confirmed illness, cat recovered; testing confirmed below-required Thiamine levels • Company has initiated corrective actions; product recall limited to specific lot • Consumers advised to stop feeding and return for full refund; contact: cs@gorawllc.com Original Press Release: www.fda.gov/safety/rec... #FDA #USFDA

FDA launches NextGen Portal to streamline biomarker qualification submissions and meetings, enhancing efficiency and transparency. • New portal for LOI, QP, FQP submissions, tracking, and communication • Pre-submission and debrief meetings available, with detailed request procedures • Guidance on qualification stages, content elements, and meeting requests • Emphasis on structured drafts for faster review and clearer communication • Supports evolving drug development tools under the 21st Century Cures Act Original Press Release: www.fda.gov/drugs/biom... #FDA #USFDA

New report reveals trends in U.S. pharmaceutical quality, including manufacturing compliance, recalls, and emerging surveillance methods for FY 2024. • Annual data on drug supply chain quality, postmarket defects, import alerts, and warning letters • Highlights progress and challenges in ensuring safe, effective medicines • Informs regulatory decisions and quality oversight strategies • Compares with prior years’ reports to track industry improvements Original Press Release: www.fda.gov/about-fda/... #FDA #USFDA

FDA seeks new members for Pulmonary-Allergy Drugs Advisory Committee with 4 vacancies, including chair position; nominations open. • Current members include pediatric allergy, pulmonary, biostatistics, and industry experts • Terms range from 2022 to 2027, with industry and consumer reps involved • Vacancies may impact upcoming drug review panels and policy decisions • Nomination process ongoing; final appointments pending Original Press Release: www.fda.gov/advisory-c... #FDA #USFDA

FDA Seeks Nominations for Medical Imaging Drugs Advisory Committee • 11 vacancies, including chairperson and consumer rep positions • Experts in radiology, molecular imaging, biostatistics sought • Terms through mid-2027, open for qualified nominations • Industry and consumer roles currently vacant • Focus on advancing imaging drug evaluation and safety Original Press Release: www.fda.gov/advisory-c... #FDA #USFDA

FDA completes key biosimilar review and transparency milestones under BsUFA II, including guidance updates and program assessments. • Final guidance on communication, biosimilarity demonstration, and interchangeability issued between 2016-2019 • Independent assessments of review transparency published in 2020 and 2022 • Quarterly hiring updates and public meetings on resource management held through 2022 • Financial plans and program evaluations updated annually from 2018 to 2022 Original Press Release: www.fda.gov/industry/b... #FDA #USFDA

Early alert: Trividia issues correction for TRUE METRIX glucose monitors after 114 injuries, 1 death linked to E-5 error code. • Affected models: TRUE METRIX, AIR, GO, PRO • Updated instructions emphasize immediate medical attention for E-5 errors with high glucose symptoms • Devices display >600 mg/dL or test strip errors, risking delayed treatment • Trividia reports serious adverse events, including death, since Jan 2026 • Distributors, providers urged to notify patients, post correction notices • Ongoing review; public updates expected Original Press Release: www.fda.gov/medical-de... #FDA #USFDA

FDA issues warning for Elanco over misleading promotion of Pradalex in cattle and swine; false claims about efficacy and treatment protocols. • Promotional materials falsely label Pradalex as “first-pull treatment” despite label cautions against early use • Claims of effectiveness against “all relevant pathogens” overstated; excludes key pathogens like Bibersteinia trehalosi and Actinobacillus pleuropneumoniae • Advertisements imply faster recovery times based on in vitro data, not clinical evidence • Misleading “power” and “less than half the time” claims lack supporting clinical validation • Violations linked to antimicrobial resistance concerns, especially for critically important fluoroquinolones • Response required within 15 days to address violations and cease misleading claims www.fda.gov/inspection... #FDAWarningLetter

FDA issues warning for CGMP violations at Australian drug facility; highlights inadequate testing, process validation, and equipment qualification. • Failed to ensure batch-specific testing for identity, strength, and contaminants before release • Inadequate validation of manufacturing processes and environmental controls • Non-compliant equipment qualification and cleaning validation procedures • Facility ceased U.S. drug production; must address systemic CGMP deficiencies before resuming • Drugs placed on import alert; firm must respond within 15 days to corrective actions www.fda.gov/inspection... #FDAWarningLetter

FDA issues warning to Fidelity Melon for FSVP violations in melon imports • Failed to develop, maintain, or follow an FSVP for imported vine melons and seedless watermelons • Did not review or verify foreign supplier certifications, only collected documentation • No evidence of risk-based activities or compliance with produce safety standards • Inspection conducted Dec 17 & Jan 2, 2025; firm states no imports during 2025/2026 season • Firm must respond within 15 days with corrective actions or face potential import restrictions www.fda.gov/inspection... #FDAWarningLetter

FDA issues warning to investigator for protocol violations and overdosing in clinical trial; inadequate corrective response noted. www.fda.gov/inspection... #FDAWarningLetter

FDA issues warning to Australian drug manufacturer for CGMP violations including inadequate batch testing, process validation, and equipment qualification. • Multiple violations from March-April 2025 inspection, including failure to confirm drug identity and strength before release • Inadequate validation of manufacturing processes and cleaning procedures for U.S.-bound products • Equipment not properly qualified for intended use, with insufficient cleaning validation protocols • Firm to cease U.S. production, respond within 15 days with corrective action plans • Import alert and detention of all products from facility remain in effect Original Press Release: www.fda.gov/inspection... #FDA #USFDA

FDA issues warning for protocol violations at clinical site; overdosing of investigational drug in all four subjects raises safety and data integrity concerns. Original Press Release: www.fda.gov/inspection... #FDA #USFDA

FDA releases bi-weekly list of approved drugs with Competitive Generic Therapy designations, highlighting exclusivity and market milestones. • Recent approvals include $Pseudoephedrine$ (OTC, Dec 2025) and $Cephalexin$ (Oct 2024) with CGT status • List details NDA/ANDA numbers, active ingredients, approval dates, and exclusivity eligibility • Notable forfeitures: drugs not marketed within 75 days, e.g., $Risperdal Consta$ (Nov 2025) • Provides transparency on CGT impact on generic competition and market entry timelines • Orange Book updates CGT codes and expiration dates for first-approved drugs with 180-day exclusivity Original Press Release: www.fda.gov/drugs/gene... #FDA #USFDA

Travelers Companies (TRV) director Rafael Santana to step down after 2026 Annual Meeting due to increased commitments at Wabtec Corporation. - Santana informed Travelers on February 13, 2026, of his decision not to seek re-election. - He will serve through the 2026 Annual Meeting to ensure an orderly transition. - Departure reflects personal capacity constraints, not company disagreement or strategic change. #Form8K #BoardUpdate #CorporateUpdate Full summary: www.perivis.com/note/d... $TRV.US

Advanced Micro Devices (AMD) grants CEO Lisa Su a $75M performance-based equity award tied to stock price growth over five years starting March 2026. - Award vests through 2031 with hurdles from 10% to 20%+ CAGR and a $600 stock price target - Five top executives receive 2025 cash bonuses totaling over $7.5M, payable March 2026 - Award requires Su to remain CEO or Executive Chair for vesting eligibility #Form8K #ExecutiveComp #InvestorUpdate Full summary: www.perivis.com/note/5... $AMD.US

American Electric Power Company, Inc. (AEP) announced that Board member Henry P. Linginfelter will not seek re-election at the 2026 Annual Meeting of Shareholders. - Linginfelter’s departure is voluntary and unrelated to any company disagreements - No successor has been named ahead of the 2026 meeting - Board size will decrease unless a new director is appointed or elected at the meeting #Form8K #BoardUpdate #Governance Full summary: www.perivis.com/note/2... $AEP.US

Republic Services (RSG) projects 2026 revenue between $17.05B and $17.15B with net income forecasted at $2.20B to $2.22B - Adjusted diluted EPS expected in the range of $7.20 to $7.28, excluding restructuring charges - Adjusted EBITDA forecasted between $5.475B and $5.525B, including $25M restructuring costs - Free cash flow projected at $2.52B to $2.56B with capital expenditures near $2.0B #Form8K #EarningsUpdate #InvestorUpdate Full summary: www.perivis.com/note/c... $RSG.US

Palo Alto Networks (PANW) reports Q2 fiscal 2026 revenue of $2.6B, up 15%, and raises full-year Next-Gen Security ARR guidance to $8.52-$8.62B - GAAP net income rose to $432M, or $0.61 per share, compared to $267M a year ago - Next-Gen Security ARR grew 33% YoY to $6.3B; Q3 ARR guidance up ~56% YoY - Remaining performance obligation increased 23% to $16B, signaling strong backlog - Integration of Chronosphere and CyberArk underway to expand cybersecurity portfolio #Form8K #EarningsUpdate #InvestorUpdate Full summary: www.perivis.com/note/d... $PANW.US

Consumer Financial Protection Bureau's costs to consumers estimated in new research * Analysis of regulatory expenses and their impact on consumer costs * Highlights potential savings from recent policy changes * Examines fee structures and enforcement actions * Provides comparative data on industry compliance costs * Offers policy recommendations to reduce consumer burden www.whitehouse.gov/res... #WhiteHouse #Research

President issues message marking Ramadan, emphasizing unity, reflection, and support for Muslim communities worldwide. * Highlights importance of religious tolerance and cultural understanding * Calls for solidarity against hate and discrimination * Reaffirms commitment to religious freedom and inclusivity * Encourages Americans to celebrate diversity during Ramadan * Promotes peace and mutual respect across communities www.whitehouse.gov/bri... #WhiteHouse #BriefingsStatements

President issues message celebrating Lunar New Year, emphasizing unity and cultural heritage * Highlights importance of diversity and inclusion * Calls for renewed commitment to community values * Recognizes contributions of Asian American communities * Encourages international cooperation and peace * Promotes cultural understanding and shared prosperity www.whitehouse.gov/bri... #WhiteHouse #BriefingsStatements

AI's rapid growth could transform productivity and labor markets, but short-term disruptions pose risks; long-term gains depend on societal adaptation. • AI as a general-purpose tech with widespread adoption and innovation cascade • Adoption surged: 79% of large firms using generative AI by 2025, rapid workplace integration • Short-term: potential job displacement, especially for early-career workers in exposed sectors • Long-term: productivity boosts, new job creation, and possible narrowing of wage gaps • Risks: rapid AI growth may cause short-term unemployment, inequality, and structural labor shifts • Monetary policy implications: higher potential rates, inflationary pressures, and need for societal resilience Original Press Release: www.federalreserve.gov... #FederalReserve #Speech

Government of India Securities Switch Auction Announcement – February 23, 2026: The Reserve Bank of India announced a government securities switch auction for ₹25,000 crore, with bids to be submitted via the e-Kuber platform between 10:30 AM and 11:30 AM. The auction will be multiple-price based, with successful bids accepted at their quoted prices, and settlement scheduled for February 24, 2026. The process involves specific bid submission guidelines, including minimum bid size and pricing based on previous day’s FBIL closing prices. Original Press Release: www.rbi.org.in/scripts... #RBI #CentralBank #India

State Government Securities - Full Auction Results April 27, 2024: The Reserve Bank of India announced the results of the latest state government securities auction, with total allotments amounting to ₹39,450 crore across various states and tenors. The auction saw varying cut-off yields, with some states accepting additional amounts beyond the notified figures, notably Gujarat and Maharashtra. The results include details on competitive and non-competitive bids, partial allotments, and yields for each security. Original Press Release: www.rbi.org.in/scripts... #RBI #CentralBank #India

ECB extends Elderson’s Vice-Chair term until Dec 2028 amid focus on financial stability and emerging risks * Mandate approved by EU Council, aligned with ECB Governing Council proposal * Elderson to serve until end of ECB Executive Board term, Dec 2028 * Emphasizes importance of safe banks for European economic resilience * Highlights challenges: geopolitical, cyber, climate, and nature crises * Commitment to forward-looking, risk-based banking supervision Original Press Release: www.ecb.europa.eu//pre... #ECB #EuropeanCentralBank

Bitmine Immersion Technologies (BITM) outlines bullish 2026 crypto outlook with Ethereum mining focus in CoinDesk Consensus presentation - Executive Chairman Tom Lee forecasts Bitcoin rebound after 29% decline in 2025, contrasting gold’s 73% rise - Highlights Bitcoin’s historical inflation resilience versus gold’s 48% underperformance over 50 years - Positions Bitmine as a prime play on Ethereum growth amid rising decentralized autonomous tokens - Update released Feb 17 includes video, transcript, and operational commentary without new transactions #Form8K #InvestorUpdate #StrategicDeal Full summary: www.perivis.com/note/b... $BMNR.US

Twist Bioscience (TWST) announces strategic investment and licensing deal with Invenra, issuing 632,328 shares and paying $5M cash for technology and ~6% equity stake - 324,558 shares issued directly to Invenra for license and technology transfer - Additional 307,770 shares issued to Invenra investors for preferred stock conversion - Twist gains board seat and voting rights to approve two more directors - Registration Rights Agreements filed to enable resale of issued shares #Form8K #StrategicDeal #EquityIssuance Full summary: www.perivis.com/note/7... $TWST.US